||SPACEX-5 RESEARCH PAYLOADS
*This manifest does not include payloads from NanoRacks, or other outside entities whose projects jointly fly under the ISS National Laboratory. Additionally, this list does not include funded educational payloads from the Student Spaceflight Experiments Program, for which CASIS is a national sponsor. This list of payloads only includes those that have been brokered and sponsored by CASIS.
Principal Investigator: Dr. Mahendra Jain
Dr. Mahendra Jain, principal investigator for Kentucky Space, has proposed an experiment
to study regeneration in planarians, which are flatworms capable of rebuilding body
organs and nervous systems after damage.
In partnership with Dr. Michael Levin of Tufts
University, Dr. Jain will examine the effects of the space environment on these enhanced
healing abilities. Gravity, and the lack thereof, influences the way cells behave and their
ability to rebuild tissue.
Studying planarians in space may reveal new aspects of how cells
rebuild tissue, which could lead to breakthroughs in medical treatments for humans. For
example, regenerative medicine has the potential to treat conditions like Parkinson’s,
heart disease, or lost limbs.
T-CELL ACTIVATION IN AGING
San Francisco VA Medical Center, NCIRE
Principal Investigator: Dr. Millie Hughes-Fulford
Recently it has been discovered that there is altered miRNA expression in spaceflight and
Dr. Hughes-Fulford and team hypothesize that altered miRNAs expression may provide new
pharmaceutical targets for treatment of immune disease. Their goal is to elucidate the
molecular basis of suppression of T-cell activation in microgravity, including identification
of regulatory miRNA expression (with gene targets) which cause immunosuppression in
astronauts and the elderly.
This is a project funded by both the National Institutes of Health
and the Center for the Advancement of Science in Space.